West Dunbartonshire Council's planning committee approved the application to improve shopfronts, landscaping, and infrastructure at the town centre location.
The project is part of a wider investment, funded by the UK Government, which also includes the redevelopment of Glencairn House and the Connecting Dumbarton project.
The approved plans include the creation of a new public square with outdoor seating, a play park, and a striking new structure inspired by local shipbuilding heritage. The square is designed to encourage people to spend more time in the town centre.
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The redevelopment of the Artizan Centre is part of a long-term vision to transform the site into a vibrant mixed-use development, including residential, retail, and leisure spaces. Work on the first phase is expected to begin in early 2025.
Convener of Infrastructure, Regeneration and Economic Development, Councillor David McBride, said: "This is a vital new step in the regeneration of Dumbarton town centre and I am delighted that this important step has been taken which help bring this vision to life.
"I am grateful for the feedback which the public has given and that our teams have focused on the comments made by residents to form these plans.
"I look forward to seeing this develop over the coming months and breathing new life into Dumbarton town centre."
Vice Convener of Infrastructure, Regeneration and Economic Development, Councillor Lawrence O'Neill, said: "This is a new chapter for the town and, along with the redevelopment at Glencairn House, those who use work, live and shop in the town centre will soon see a significant improvement to the look and feel of Dumbarton.
"It is an exciting stage in this project and one which should reap huge benefits for the businesses who currently trade in the town and help well attract more firms to operate from here."
Planning permission was granted subject to conditions.
