The works will focus on replacing ageing rail lines to drive down delays and keep services running efficiently. Due to the complexity of the engineering work, these projects cannot be delivered without a short-term closure of the line.
Kevin Haddow, project manager at Network Rail, said: "The work we are undertaking is vital for the long-term future reliability of the line.
"The four-day closure of the line allows us to carry out a huge amount of work at the same time, with engineers combining three projects to deliver the work more efficiently and limiting the time we need to close the railway.
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"We've worked closely with ScotRail to divert trains via the Singer route, to keep passengers on trains wherever possible.
"We understand the inconvenience these works will cause to some passengers and residents and we thank them for their patience. We are committed to completing this work as quickly as possible for our customers."
David Simpson, service delivery director, ScotRail, said: "We are sorry to customers for the inconvenience they will face during these essential works by our colleagues at Network Rail Scotland.
"While the line is closed, we will be doing everything we can to keep customers moving, by diverting some services and adding replacement buses.
"Customers should check their journey before they travel on our social channels, our website, or the ScotRail app."
