On the west coast main line, which links Glasgow Central to London Euston, engineers will renew tracks at a range of locations including Ecclefechan, Carstairs, Beattock and Abington to help improve the reliability of services.
The programme of work this Easter is part of a five-year, £4bn investment in Scotland's Railway helping to make our infrastructure more resilient and more reliable.
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Most of the country's services are unaffected by Easter's investment programme, but due to the complexity of the engineering work, these projects cannot be delivered without some short-term closures of the line.
Network Rail has also reminded passengers of ongoing improvement works on the Argyle line, impacting services between Exhibition Centre and Rutherglen.
Liam Sumpter, Network Rail route director for Scotland, said: "This investment programme is vital for the future of Scotland's Railway.
"The work we are undertaking this Easter weekend will help to provide a more modern railway and will help to improve reliability on the west coast main line – one of Europe's busiest rail routes.
"We understand the inconvenience this work will cause some customers, but such a significant investment cannot be delivered without temporary disruption and every effort has been made to reduce the impact of our activities as much as possible."
