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The site at Montrose produces ingredients for vaccines for illnesses including tetanus, pneumonia and whooping cough.
Speaking while opening the new facility, First Minister Nicola Sturgeon said GSK's latest expansion "is a boost for our life sciences industry".
"GSK has been in Montrose for more than 60 years, and I am delighted they chose this site as their dedicated vaccines facility," she said.
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"As well as creating very highly skilled jobs, the site will also be critical to helping to vaccinate millions worldwide against preventable diseases."
GSK Montrose Site Director, Les Thomson, said: "Montrose was able to be considered for this investment by GSK because we have the right mix of people and skills.
"We know Scotland is a good place to conduct research, development and manufacturing, and we're pleased the Scottish Life Sciences Strategy demonstrates a shared commitment between the industry and Scottish Government to ensuring Scotland remains a great place to work in life sciences."
(LM/MH)
